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George Lopez has been a good friend to Sandra Bullock while she went through her divorce from Jesse James and now it’s her turn to repay the favor. George and his wife Ann Lopez have decided to split up.

OK! NEWS: GEORGE LOPEZ HELPED SANDRA BULLOCK KEEP ADOPTION SECRET

“George and Ann Lopez have made the decision to end their 17-year marriage,” the couple’s rep said in a statement to Extra. “The decision is amicable and by mutual agreement.”

“They remain dedicated parents, and committed partners in business and their philanthropic organization, The Lopez Foundation.”

OK! GALLERY: GEORGE LOPEZ PAYS PAL SANDRA BULLOCK ANOTHER VISIT

George married Ann in 1993 and in 2005 Ann donated one of her kidneys to George due to a genetic condition the talk show host suffered from.

They have a 15-year-old daughter together.

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