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Another Hollywood marriage is coming to an end. Probably.

Dennis Quaid's wife, Kimberly Buffington-Quaid, has filed to separate from her actor husband — for the second time this year.

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Kimberly is requesting joint legal and sole physical custody of their 4-year-old twins, Thomas and Zoe.

She has enlisted celebrity pit bull attorney Laura Wasser to help her get the spousal support and legal fees she is requesting.

"Kimberly and Dennis Quaid have decided to legally separate after eight years of marriage," the actor's rep told People on Friday.

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"They ask that their privacy and the privacy of their family be respected during this difficult time."

Just three months ago, the couple went for a make-or-break vacation to Bora Bora to celebrate their eight-year wedding anniversary.

Kimberly had filed for divorce in March but withdrew her papers just two months later. The documents stated at the time that things between them had "become insupportable because of discord or conflict of personalities."

The couple's relationship has certainly had its ups and downs, including the traumatic time in 2007 when their twins nearly died soon after birth because they were accidentally given an overdose of the drug Heparin while in hospital. They parents were awarded $750,000 after filing a lawsuit against the drug manufacturer.

Dennis, who currently stars in Vegas, was previously married to Meg Ryan but they divorced in 2001. They are parents to a 20-year-old son, Jack. His first marriage, to Halloween actress P.J. Soles in 1978, ended in 1983.

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