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Christopher Ciccone, whose brutal tell-all on sister Madonna hits shelves tomorrow, has his issues with big sis, but he will be the first to defend allegations that she broke up Alex Rodriguez‘s marriage.

"I think it’s highly unlikely," Christopher tells Good Morning America in a two-part interview. "Despite everything else, she’s still a Catholic girl."

Adding that he knows the New York Yankee from Miami, the 47-year-old believes the purely platonic relationship between the two stem from their affinity for kabbalah.

"I doubt this is actually an affair," he says. "I’m sure she had nothing to do with the breakup of their marriage. It seemed absurd to me, truly, I don’t believe it."

Last week, A-Rod’s wife Cynthia filed for divorce over his "affair of the heart" with Madonna.

While Christopher is friendly with Alex, the same can’t be said of his relationship with Guy Ritchie. Once tight with his sister — they had phone conversations every night before bed and every morning after waking up — Christopher reveals in Life with My Sister Madonna that the falling out between them was the result of her romance with the British director.

"Guy Ritchie pretty much happened to our relationship," he says. "The best way to get to my sister was to get into bed with her…the last person to speak to her at night has a lot of influence. We both couldn’t exist in the same hemisphere."

Christopher, who’s openly gay, even goes as far to suggest Guy may be homophobic, recalling an incident when he was helping the two redecorate their home.

"When it comes to selecting the wood for his closet, I show him 12 samples and he tells me that they all look ‘twee,’ using the word over and over," Christopher writes. "I get the message: I am gay and he doesn’t want the house to reflect my sexuality, which is hardly likely."

Despite their differences though, Christopher is wishing the couple the best during this media maelstrom and believes Madonna will pull through.

"I believe she’ll do what’s best for the family and her kids and I think she’ll do her best to maintain the marriage and keep it going," he says. "She’s not the kind of person to walk away."

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