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George Clooney and a slew of other celebrities have united with Bono for the One campaign in a brand new PSA where they stand against the “F Word.”

“Famine is the real obscenity,” is the motto of the campaign, as the organization urges Americans to fight the emergency of global AIDS and extreme poverty.

OK! VIDEO: WATCH SCARLETT JOHANSSON’S PSA TO SUPPORT PLANNED PARENTHOOD

Joining George in the star-studded PSA are Jessica Alba, Colin Farrell, Kristin Davis, Clive Owen, Idris Elba, Evan Rachel Wood, Rob Lowe, Joe Jonas, NYC Mayor Michael Bloomberg and model Christy Turlington.

For more on the cause, visit One.org and catch the PSA below.

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