Argireline Peptide: Skin Cell Studies

Argireline Peptide: What is it?

Argireline is a trademarked peptide known as acetyl hexapeptide-3 (or acetyl hexapeptide-8). This peptide is a manufactured compound consisting of six amino acids. It is commonly found in research products that aim to impact the depth of wrinkles and creases along the skin surface.

Studies suggest that Argireline may function by inhibiting the activation of neurotransmitters that control movement in certain muscle groups. Through its mechanism of action, the peptide has been hypothesized to potentially reduce the depth of wrinkles by minimizing the occurrence of muscle contractions, thereby limiting subtle contractions. In particular, Argireline has been theorized to prevent the creation and durability of the protein complex necessary for the attachment of acetylcholine-release vesicles without causing any harm to the subject, even when given in high concentrations.

Argireline was developed as an alternative to botulinum neurotoxin (BoNT). Research suggests that the effectiveness of a product containing Argireline would depend on various factors, such as the formulation and purity of the acetyl hexapeptide-3 it contains. In scientific research, a topical cream with a 99% acetyl hexapeptide-3 purity level is considered the highest standard.

Argireline Peptide Potential

Multiple scientific studies have purported that Argireline may have various potential physiological properties, more frequently associated with skin cell and epidermal research.

Argireline Peptide and Wrinkle Depth

Acetyl hexapeptide-3 has been extensively researched and has consistently suggested its potential to decrease the depth of wrinkles, particularly in the lateral periorbital areas where dynamic folds tend to form. As an example:

●During a study conducted in 2010, researchers speculated a significant decrease in wrinkle depth within a mere 24 hours of exposure to Argireline. After one month of presentation, researchers indicated significant reductions in wrinkle depth, with some cases showing a decrease of up to 78.25%.

●A study was conducted to evaluate the potential and effectiveness of the hexapeptide. The results suggested that the side presented with a 10% hexapeptide emulsion appeared to have a significant % antiwrinkle effect of 48.9%, while the placebo seemed to have no effect.

●In a separate study, ten research models were exposed to a 10% acetyl hexapeptide-3 emulsion twice daily for 30 days. The test subjects were given the test emulsion to one side of the periorbital region while applying an emulsion without the hexapeptide to the opposite side. The study findings implied a significant reduction in wrinkle depth on the side presented with acetyl hexapeptide-3 compared to the side that did not receive any substance.

Argireline Peptide and Collagen

Collagen is a vital protein that is considered to play a role in maintaining the elasticity and flexibility of the skin. Furthermore, collagen may play a crucial role in the skin's healing process by stimulating the generation of new cells to repair damage. Over time, collagen starts to break down, fibroblast function decreases, and production decreases.

A study on aged rodents in China purported that applying acetyl hexapeptide-3 twice daily for six weeks may have increased type 1 collagen fibers. This result is important as it highlights the potential of boosting collagen fiber production to preserve skin elasticity.

Argireline Peptide and Hydration

Ensuring adequate hydration is considered an essential safeguard agains the premature degradation of skin cells. However, as the skin cell continues to divide, its capacity to retain moisture decreases.

Argireline has been hypothesized to address decreased hydration potentially. It was stated in one research study that acetyl hexapeptide 8 exposure indicated notable improvements in reducing wrinkles and increasing skin hydration. Study is ongoing, however.