Clooney, 53, and his 36-year-old wife said their “I do’s” for the second time at Venice's Palazzo Ca'Farsetti Monday.
The ceremony was conducted by Clooney’s close friend, Walter Veltroni. The former mayor of Rome also conducted their wedding on Saturday.
The human rights lawyer wore a cream floppy-brimmed hat to match her pantsuit while the actor wore a grey suit.
The official ceremony, which wed them legally under Italian law, was held in the Sala Degli Affreschi room.
Monday’s low-key ceremony marked the final event in the weekend-long wedding celebrations for the couple, joined by Bono, Cindy Crawford, Matt Damon, Bill Murray and more.
Amal and George arrived in Italian on Thursday for the Venetian wedding and spent their Friday evenings separate with friends before the Saturday union.