Lindsay Lohan as Cady Heron: "In the real world, Halloween is when kids dress up in costumes and beg for candy. In Girl World, Halloween is the one day a year when a girl can dress up like a total slut and no other girls can say anything else about it."
Lizzy Caplan as Janis Ian: “She’s a life ruiner. She ruins people’s lives.”
Lacey Chabert as Gretchen Wieners: “That’s so fetch.”
Rachel McAdams as Regina George: “Boo, you whore.”
Amanda Seyfried as Karen Smith: “On Wednesdays we wear pink.”
“It’s not my fault you’re, like, in love with me or something!”
Amy Poehler as Mrs. George: “I’m not a regular mom, I’m a cool mom."
Tina Fey as Ms Norbury: “I’m kidding. Sometimes older people make jokes too."
Daniel Franzese as Damian: “That’s why her hair is so big: It’s full of secrets.”
“You go, Glen Coco!"
“You can’t just ask someone why they’re white.”
“The limit does not exist.”
Tim Meadows as Mr. Duvall: "Miss Smith, why would Regina refer to herself as a 'fugly slut?'"
Jonathan Bennett as Aaron Samuels: "Grool."
Rajiv Surendra as Kevin Gnapoor: "Yo, yo, yo. All you sucka MC's ain't got nothing on me, from my grades to my rhymes you can't touch Kevin G. I'm a mathlete, so nerd is inferred but forget what you heard I'm like James Bond the third. Shaken not stirred I'm Kevin Gnapoor. The G's silent when I sneak in your door. I make love to your woman on the bathroom floor. I don't play like Shaggy, you'll know it was me, cuz the next time you see her she'll be like 'ohhh Kevin G.'"
Ana Gasteyer as Cady's Mom: "You love Ladysmith Black Mambazo!"