Jamie, 51, and the unidentified woman were seen leaving Bootsy Bellows in West Hollywood.
She dressed to impress in a sexy number while Jamie appeared casual for the west coast outing.
The mystery lady looked perfectly comfortable next to Jamie after departing from the venue.
Does this mean Jamie is done with his longtime girlfriend Katie, 40? They just made their red carpet debut at the 2019 Met Gala in May after being linked together as far back as 2013.
His daughter Corinne confirmed their relationship during an interview with PEOPLE that same month.
Jamie and Katie have been notoriously secretive about their coupling for years. They have never spoken about each other in the media and are rarely seen out together.
The former Dawson's Creek star has been seen out in New York City with her daughter Suri several times this summer. They were spotted shopping in Chinatown in July and recently saw the Broadway adaptation of Moulin Rouge.
Do you think Jamie and Katie are over? Sound off in the comments!