The multi-award winning series announced the exciting news via its Instagram page on Thursday with three index cards on a cork board.
Gosling will be there to promote his much-anticipated film Blade Runner 2049, which will be released the week after the premiere on October 6th.
Jay-Z is expected to perform tracks from his critically acclaimed album 4:44, which hit number one on the Billboard charts back in July.
This is the second time hosting for Gosling and the fourth time performing for Jay-Z. Gosling had some memorable and hilarious slips up when he hosted his first time back in December 2015 as he giggled through some of the skits.
Are you excited to see Ryan & Jay-Z on the premiere? Sound off in the comments!