The "Rack City" emcee was seen getting into an altercation inside the party, which took place at Jadelle's in Beverly Hills.
Other attendees included Tiffany Haddish and French Montana.
Video showed him being dragged out of the space by security and onto the street after the scuffle.
The burly security guard and Tyga were then spotted outside the doors of Jadelle's.
Tyga then appeared to have gotten into a war of words with another security member.
No word yet as to why the situation at Jadelle's went down.