The romantic comedy was released in 1988 and starred Eddie, 58, as Prince Akeem, a royal from the fictional African nation of Zamunda. He travels to Queens, New York, to find himself a wife as he works in a fast food restaurant.
Wesley, 57, is set to play General Izzi, the ruler of another fictional African nation that borders Zamunda.
The sequel, entitled Coming 2 America, will follow Akeem returning to America 30 years later to find his long-lost son.
Ghostbusters actress Leslie Jones and If Beale Street Could Talk star Kiki Layne are also attached to star in Paramount's film.
Arsenio Hall will reprise his role of Akeem’s best friend, Semmi. Coming to America also starred James Earl Jones, Shari Headley and John Amos.
The film will premiere in August 2020.
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