Since Zach Galifianakis smoking a joint on his show did so well, Bill Maher decided to shoot The Hangover Part II star with heroin this time on Real Time with Bill Maher. And Zach went along with it since the end of the world was coming anyway!
Bill explained to Zach that the clip of him smoking a joint on his show in October 2010 "got over 2 million hits on YouTube."
So Bill decided to take it up a notch this time and pulled out a tray of paraphernalia to shoot Zach up with what he said was heroin.
"Never done this before in my life," Zach said. "Yeah, everything's ending, so let's just do it."
Unfortunately for Zach, the world didn't actually come to an end over the weekend. So it looks like the star will have to deal with the aftermath of shooting up live on the air!
Watch the clip, below!