Hollywood has a heavy heart this morning as the producer of Pretty Woman and Spider-Man movies, Laura Ziskin, has passed away. She also co-founded Stand Up to Cancer, a charity that’s raised more than $200 million for cancer research.

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Laura was diagnosed with breast cancer in 2004 and fought it until the very end, at age 61. Prior to her death, Laura worked on the upcoming Spider-Man film. Although she was perhaps most known for her work with those films, her career lasted for three decades and she was involved with a bunch of movies including No Way out, Fight Club and As Good As It Gets.

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According to the BBC, Stand Up to Cancer co-founder Katie Couric, described Laura as “one of the most courageous people I’ve ever known.”

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