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VIDEO: Katherine Heigl Says 'Grey's Anatomy' is "Over For Me Now"

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Oct. 1 2010, Published 9:53 a.m. ET

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Katherine Heigl says she really done with Grey's Anatomy, but that doesn't mean she doesn't wonder about what Izzie's life would be like now.

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"That chapter is closed, and it's sad," Katherine told MTV News at the Life As We Know It premiere in NYC on Thursday night. "And it's hard."

Katherine left the show in January, but left her character's storyline missing some closure.

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"I can't think of any way that she could come back gracefully that wouldn't just feel manipulative," she said. "And, it's hard, because I really wonder what she's doing and where she is and what happened, but that is over for me now."

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And there doesn't appear to be any bad blood between Katherine and Grey's Anatomy as she said she really does miss it.

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"I really miss that relationship," Katherine said of her character's romance with Alex. "Justin Chambers is one of the most amazing men, and certainly a spectacular actor. I feel oddly attached to him, and the character and my character being together. It just seems what's supposed to be, but you can't have it all."

Watch Katherine's red carpet interview below!

Life As We Know It hits theaters Oct. 8!

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