Brad, 55, sported a long sleeve navy shirt, black jeans, a blue hat and a medley of woven bracelets for the photocall.
Hot off of the success of his black comedy, Once Upon A Time In Hollywood, the father of six is back on the red carpet for his next blockbuster.
Liv, 42, donned a pink, purple and yellow midi dress and black suede pumps. She let her dark locks fall onto her shoulders and wore bright makeup.
Ruth, 37, rocked a gold and navy jumpsuit and gold sandals. The Preacher star opted wear dark lipstick and smoky eyes to the screening.
The space-adventure film follows an astronaut, played by Brad, who must venture out into the solar system to find his long-lost father.
Ad Astra premiered at the Venice Film Festival on August 29 but will officially hit American cinemas on September 20.
Will you head out to the theaters to see Ad Astra? Sound off in the comments below!