Richard Harris filmed the first two Harry Potter movies as Dumbledore and begged the director not to replace him when he received a Hodgkin’s diagnosis. He died in 2002 and was replaced by Michael Gambon.
Rizzoli & Isles has stated that star Lee Thompson Young, who committed suicide in 2013, will be honored in the first two episodes of season five.
Aaliyah had filmed part of her role in in The Matrix: Reloaded before her fatal plane crash in 2001, but she was replaced by actress Nona Gaye.
John Ritter's character on 8 Simple Rules for Dating My Teenage Daughter died shortly after he did in 2003.
After Cory Monteith's tragic drug overdose in 2013, his character Finn on Glee was killed off camera, and honored with a tribute episode.
James Gandolfini left several projects in production when he died in 2013. In the case of his HBO drama Criminal Justice, he will be replaced by Robert DeNiro.
Heath Ledger died one-third of the way through production for The Imaginarium of Doctor Parnassus, and his role was bizarrely taken over by Colin Farrell, Johnny Depp, and Jude Law, who played his character in different stages of a dream world.
There has been word that Philip Seymour Hoffman's character in the final two Hunger Games films will be created with a CGI version of Hoffman following his death from a drug overdose.