The situation has presented a problem, at least from NeNe's side, as she called him "mean, grouchy and evil" on her social media late last week.
She also said in an interview that his diagnosis has been hard on their marriage and that they don't sleep in the same bed anymore.
Gregg decided go the positive route and praise his longtime wife on Instagram Friday by penning a truly sweet note for her.
"This woman right here has put a mountain on her back and carried it with grace," he wrote. "She's given so much of herself. You NeNe, steps up to the plate, bats and knocks it out of the park every single time."
He then brought up her frustrations, saying "So what she hit a wall and her cup run over! Pray for her, encourage her, lift her up. What good is tearing down gonna do?"
What are your thoughts on Gregg's words for NeNe? Sound off in the comments!