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Dennis Quaid is ready to say goodbye to Hollywood.

No, he’s not retiring from acting, but he is moving.

"The train is going down the tracks!" he tells Extra.

The actor and his wife, Kimberly, are planning to uproot their family, which includes 7-month-old Thomas Boone and Zoe Grace to his hometown of Houston.

"We have a lot of family there and we have a really nice plot of land," he says. "We have 30 or 40 friends and family members within two miles of us. Its kind of a no-brainer."

Leaving Los Angeles will also put a devastating 2007 behind him. Last November, his twins nearly died from an accidental overdose of the drug Heparin. Thomas and Zoe were given 10,000 units of Heparin; the normal dosage for infants is 10 units. The children were treated and are now doing well.

"They went through a medical catastrophe. Thank God it had a happy ending," Dennis says. We took them [kids] to the kiddie pool for their first swim today. They loved it.

The 54-year-old and his wife have since taken action to prevent such medical nightmares from happening again by establishing a foundation to minimize the impact of human error.

"We would like to start by bar coding," he says. "With a bar code, [a nurse] can scan the medicine and scan the bracelet of the patient. Scan her own tag and if theres a mistake, it will come up."

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