Giuliana Rancic’s Fading Frame Through The Years

Giuliana was all smiles at a Richard Tyler fashion show in October 2003. The then-blonde sported a fuller (and healthier!) face.

The mother of one looked happy and healthy in 2005, the same year she became an E! News anchor.

Red hot! Giuliana flaunted her cleavage in a figure-hugging red dress at the Vibe Awards.

At an event in September 2008, Giuliana showed how low (and skinny!) she could go in a mini dress. “They were accusing me of every eating disorder,” she recently told People magazine. “I thought to myself, 'God, if someone really thought I had an eating disorder, what a horrible way to approach it.’”

The reality star covered up her protruding collarbone with a sexy green number at an event in May 2009.

Giuliana looked gaunt at a marathon in August 2010. Hopefully she didn't burn off too many calories during the run!

Duke’s mom may have covered up her arms with a blazer in April 2011, but her collarbone was on full display.

After beating breast cancer, Giuliana started appearing more gaunt. “I started noticing that I was eating a lot, but not gaining weight at all,” she said. “I was concerned.” Her oncologist explained that the cancer-suppressing drug she has been taking since 2012 could cause weight loss.

At the 2014 Grammys, Giuliana showed off her barely-there waist. "I'm sorry that some people think I'm disgustingly skinny, as they put it, but there's nothing I can do,” she explained. “I'm lucky that I even have the type of cancer that reacts to the medicine."