The former couple — who met in 2008 during the audition process for The Rum Diaries — was married from 2012 until their volatile split in 2016. Their divorce was finalized in 2017.
This isn't Heard's first rocky romance, from her 2009 arrest for allegedly hitting ex Tasya van Ree to her on-and-off fling with tech mogul Elon Musk, the Aquaman actress has had her fair share of headline-making relationships.
Scroll through the gallery below to see some of Heard's most famous dates.
Tasya Van Ree (2008–2012)
Heard dated van Ree — who works as a painter and professional photographer — for four years. They considered each other domestic partners, and Heard even changed her last name to "van Ree" in March 2008. However, in 2009, Heard was arrested for domestic violence after allegedly grabbing and striking the artist's arm during an argument at the airport.
The All the Boys Love Mandy Lane star legally changed her name back to Heard after their 2012 breakup.
Cara Delevingne (2016)
Following her turbulent split with the Pirates of the Caribbean actor, Heard was rumored to be linked to English model Cara Delevigne. Although their relationship was never confirmed, they were photographed out and about together several times in 2016.
Elon Musk (2016–2018)
Heard had an on-and-off relationship with Musk from 2016 until they called it quits for good in 2018. Dr. Dawn Hughes recently testified that the actress was "heartbroken" from her split with Depp during her relationship with the billionaire entrepreneur, noting Heard's "soul was dead" and she "felt nothing" for Musk.
Vito Schnabel (2018)
Not long after her breakup with the tech giant, The Stepfather actress sparked rumors she was getting cozy with art dealer Vito Schnabel. They reportedly split several months later due to struggling with the relationship being long distance, according to sources per Us Weekly.
Andrés Muschietti (2019)
In 2019, Heard was said to be dating It director Andrés Muschietti after the rumored lovebirds were photographed several times looking like a couple. The low-key romance was not publicly confirmed by either Heard or Muschietti, and appeared to end within a few months.
Bianca Butti (2020–2021)
The Aquaman and the Lost Kingdom actress was spotted locking lips with cinematographer Bianca Butti in January 2020 while out and about in Palm Springs, California. The couple reportedly continued to date for over a year, but split in December 2021.
"With not being in the same country for months at a time and dealing with a new baby, it leaves very little time for romance," a source spilled to The Mirror, "and things look like they have fizzled out between them."