The fan-favorite actress turned 53 on Friday, February 11, and to celebrate the milestone, OK! is taking a look back at her best moments as a Hollywood A-lister.
Scroll through the images below to see Jennifer Aniston's most memorable moments through the years!
Jennifer Has Her Big Break On 'Friends'
Aniston first got her big break in the industry with her famous role as Rachel Green on NBC's sitcom Friends.
The Central Perk gang went on to film 10 seasons together on their Emmy-winning show, which took home an award for Outstanding Comedy Series in 2002.
Jennifer Begins Dating Brad Pitt
Aniston first started dating Brad Pitt in 1998 after the two were set up on a blind date. The two Hollywood treasures went on to become one of the industry's hottest couples at the time.
They made their first public debut as a duo at the Emmy Awards in 1999 before tying the knot in 2000. A year later, Pitt guest starred on Friends for the Season 8 Thanksgiving episode.
Jennifer Wins Her First Emmy
In 2002, the brunette bombshell brought home her first Emmy Award for Outstanding Lead Actress in a Comedy Series for Friends.
She has been up for a total of eight Emmys throughout her career, including her 2021 nomination for Outstanding Variety Special for her role as Executive Producer on Friends: The Reunion.
Jennifer & Brad Go Their Separate Ways
To their fans' dismay, Aniston and Pitt announced their split in 2005 after spending seven years together.
The reason for their divorce has long been rumored to have been caused by Pitt's apparent affair with his Mr. & Mrs. Smith costar Angelina Jolie, who he would later married — and divorced!
Jennifer's Love Life Flourishes After Brad Pitt
Following her divorce from the Moneyball actor, Aniston's love life continued to move right along.
She went on to date a series of notable celebrities, including Gerard Butler, John Mayer and her costar in The Breakup, Vince Vaughn. She is also believed to have had flings with Paul Rudd and Paul Sculfor, both of whom appeared as guest stars on Friends. She even apparently dated Bradley Cooper for a brief period of time!
Jennifer Ties The Knot Again
Aniston eventually settled down again, this time with fellow actor Justin Theroux, whom she met on the set of Tropic Thunder in 2007. After several years together, Theroux proposed to the never-aging actress in August 2012.
Jennifer Goes Through Her second Divorce
Jennifer Appears On 'The Morning Show'
In 2019, Aniston embarked on a new TV series entitled The Morning Show, where she partners with fellow A-lister Reese Witherspoon in the Apple TV drama.
Following the series' debut, Aniston was nominated for an Emmy for her role as Alex Levy on the hit show, along with costars Steve Carell and Mark Duplass, who were also nominated for their performances.
Jennifer Returns For The 'Friends' Reunion Special
Last year, Aniston and the rest of her Friends castmates fulfilled their fans' dreams by making a return to the show's iconic set at Warner Brothers studios.
During the reunion special, the Just Go With It star admitted to having a crush on Schwimmer, who played her on-screen love interest Ross Gellar. David confessed the feelings were mutual, although they both insisted nothing romantic ever went down between them behind the scenes.