"On the days I feel I should be the happiest... I feel so down," the 33-year-old admitted.
The "Juice" singer said that people had said things about her "that just doesn't even make sense."
"It's fat-phobic, and it's racist and it's hurtful. If you don't like my music, cool. If you don't like 'Rumors' the song, cool," she continued. "But a lot of people don't like me because of the way I look."
"It's like it doesn't matter how much positive energy you put into the world, you're still going to have people who have... something mean to say about you," she explained. "And for the most part it doesn't hurt my feelings; I don't care. I just think when I'm working this hard, my tolerance gets lower. My patience is lower. I'm more sensitive and it gets to me."
The singer said that she has not been able to congratulate herself after releasing a song where she "said everything I wanted to say." "I make music that I like, that's important to me, and I make music that I hope helps people," she added.
"I'm not making music for white people. I'm not making music for anybody. I'm a Black woman making music. I make Black music, period. I'm not serving anyone by myself... Everyone's invited," the "Good as Hell" singer said.
Lizzo went on to say that she was going to focus on the positive comments going forward. "I don't have time for your negativity, your internalized self-hatred that you project onto me with your racism and your fat phobia. I don't have time for it. Anyways, I'm going to continue to be me," she said.
"What I won't accept is y'all doing this to Black women over and over and over again — especially us big Black girls," Lizzo explained. "When we don't fit into the box you want to put us in, you just unleash hatred on us. It's not cool. I'm doing this s*** for the big Black women of the future who just want to live their lives without being scrutinized or put into boxes. I'm not going to do what y'all want me to do ever, so get used to it."
Lizzo ended the Instagram Live by assuring her fans that she was alright: "F**k the haters... haters gonna do what they do. They don't know I do it for the mother****ing culture."
The rapper also took to Twitter to talk about self-love. "Loving yourself in a world that don’t love u back takes an incredible amount of self awareness & a b******t detector that can see through a** backwards societal standards…" she wrote. "if u managed to love yourself today I’m proud of u. If u haven’t, I’m still proud of u. This s***s hard."
Her "Rumors" collaborator offered her support to Lizzo. "When you stand up for yourself they claim your problematic & sensitive.When you don’t they tear you apart until you crying like this. Whether you skinny,big,plastic, they going to always try to put their insecurities on you.Remember these are nerds looking at the popular table," Cardi B tweeted.